Kickoff: Saturday, September 5 at 6:00 PM CT
Location: Hancock Whitney Stadium
TV: ESPN+
DraftKings line (Aug. 30): USA -12.5
Over/under: 52.5
The setup
South Alabama leads this tiny series 1-0 and is 10-7 in season openers. Southeastern Louisiana already has a game; the Jaguars own the history while the Lions own the live reps.
What I’m watching
SE Louisiana lost 34-28 to Houston Christian in Week 0, with Kyle Lowe completing 17 of 27 for 150 yards, 2 TD and 1 INT. The urgent issue is ball security after SE Louisiana gave it away 3 times. That has to improve before any comparison with South Alabama matters.
Personnel snapshot
- The FBS roster is rebuilding too: SE Louisiana’s Frank Scelfo is in Year 9; South Alabama’s Major Applewhite is in Year 3. South Alabama returns 5 starters—2 on offense and 3 on defense.
- The protection problem: South Alabama brings back one starting offensive lineman, led by Ethan Hubbard. SE Louisiana produced 38 sacks last season. Protection is the personnel battle most likely to change the game.
- The pressure test: Kyle Lowe led SE Louisiana’s passing in Week 0 (17 of 27 for 150 yards, 2 TD and 1 INT); Bishop Davenport returns as South Alabama’s starter (2,073 yards, 12 TD and 6 INT in 2025). The tougher first assignment belongs to Bishop Davenport: SE Louisiana produced 38 sacks last season.
Three quick analysis points
- The running-game test: South Alabama returns three backs from a rushing attack that averaged 199.8 yards, 18th nationally. The offense may be rebuilding, but its most repeatable shortcut stayed on campus.
- The roster reset: The Jaguars have won three of their last four home openers. That is not an ancient dynasty stat; it is a current habit this roster has personally seen.
- The quarterback follow-up: Kyle Lowe handled 27 pass attempts for SE Louisiana in Week 0. He completed 17 of 27 for 150 yards, 2 TD and 1 INT. South Alabama returns 3 defensive starters and ranked No. 98 nationally at creating sacks and other disruptive plays, so this was not an overwhelming pressure mismatch last year.
Prediction
I make final predictions on my TikTok/YouTube/Instagram/Facebook pages @uthinkuknowsports.
Full disclosure: I use AI tools to format my research into an article encompassing all of the information.










